Biomedical and Biosensing Optical Devices

Abstract

The course deals with the structure and principles of operation of a variety of optical instruments for medical diagnosis and optical sensors for analytes detection. It can be divided into three main parts:
a. Optical biosensors: basic optical principles used for optical biosensing such as: absorption, TIR, surface waves such as SPR, waveguides and fibers, interferometry, ellipsometry, spectroscopy (fluorescence, Raman) and discussion of biosensors properties based on these phenomena. Examples of existing sensors for the medical applications.
b. Optical properties of tissue: propagation models in tissue, scattering, absorption, change of polarization, structure of the eye and its optical properties, introduction to eye optics and vision. Interaction of lasers-tissue and lasers applications in surgery, wound healing, hair and tattoo removal, dental treatment, and vision correction. Blood oximetry will be discussed in detail as well as the search for non-invasive glucose monitoring device, bilirubin level monitoring in blood.
c. Medical optical imaging methods: Optical microscopy (standard, dark field, dark field, polarized, confocal, fluorescence, interferometric), optical coherence tomography (OCT), photo-acoustic tomography, Doppler tomography, polarimetric and spectral imaging. Examples for cancer diagnosis with optical imaging methods, modern optical microscopy techniques exhibiting superresolution.
d. Biomedical optical devices: Oxymeters, optical glucometers, lasers in surgery, laser Doppler, cosmetics, hair and tattoo removal, classical ophthalmic instruments such as slit lamp, fundus camera, tychometer, eye aberration measurement devices, eye laser corrections, OCT.

Glossary

See Abstract

Learning Outcomes

Teach the students the optical properties of biomaterials such as absorption, scattering, dispersion and polarization effects.
Teach the students principles of optical biosensors for analytes detection in the environment and for biomedical applications.
Teach optical imaging techniques applied to biomedical applications such as OCT, photoacoustic imaging and other optical microscopy modes.
Teach the students the principles of specific biomedical optical devices being used in the clinics or heavy research on the way to clinic.

Bibliography

1 Biomedical Optics: principles and imaging, Lihong V. Wang and Hsin-I Wu, Wiley 2007.
2 Laser – Tissue Interactions, Fundamentals and Applications, M. Niemz, Springer 1996.
3 Biomedical Photonics Handbook, Ed. Tuan Vo-Dinh, SPIE press, Vol. PM125.
4 Handbook of Optical Biomedical Diagnostics, Ed. Valery V. Tuchin, SPIE press 2002.
5 Lasers in Medicine, R.W. Waynant (ed.), CRC press 2002.
6 Optical Biosensors, Frances S. Ligler, Chris A. Rowe Taitt, Gulf publishing, 2002.
7 Optics of the Human Eye, by David Atchison, and G. Smith, Butterworth Heinemann ยท Published February 2000.

External Evaluator

1 Prof. Valery Tuchin, Saratov State University, tuchin@sgu.ru
2 Prof. Dvir Yelin, Biomedical Engineering, Technion, yelin@bm.technion.ac.il
3 Prof. Israel Gannot, Biomedical Engineering, TAU, gannot@eng.tau.ac.il

Responsible Academic

Prof. Ibrahim Abdulhalim, Electrooptic and Photonics Engineering Unit, BGU
abdulhlm@bgu.ac.il

Awarded ECTS

5